Dianabol - part one
Drug Class: Oral Anabolic Steroid
Pharmaceutical Name: Methandrostenolone / methandienone
Brand Name: Dianabol
Available Dose: 1,2, 5 and 10 mg tabs or 25 mg/ml in 50 ml vials
Effective Dose: 15-50 mg / day orally or 50-150 mg / week by injection
Active Life: 6-8 hours
Acne: Yes, especially in higher dosages
Water Retention: Yes, similar to testosterone
High Blood Pressure: Yes
Liver Toxic: Yes
DHT Conversion: No
Dianabol was originally released by Ciba in 1956. It has had a long stint of popularity since then, especially in the US. Until the late 70's Dianabol was all the rave. Perhaps the most popular steroid ever. Known users include every Mr.Olympia from Scott to Zane. Of course the doses used have severely increased since then.
Its popularity was also the cause of its demise. Almost a decade ago now the original D-bol was discontinued when the FDA drew the conclusion that its therapeutic uses were minimal compared to the amount of bodybuilders who were using it. But Dianabol has never been out of circulation really.
Especially the Russians appeared quite fond of it and Russian D-bol is one of the best and most marketed forms of the substance Dianabol today.
Dianabol is without a doubt one of the best, if not the best product for people who compete in non-aerobic oriented sports. It promotes drastic protein synthesis, enhances glycogenolysis (repletion of glycogen after exercise) and stimulates strength in a very direct and fast-acting way.
It may be less useful to those competing in aerobic events as it also diminishes cell respiration1. But Dianabol manifests itself in a distinct manner : rapid and fast-acting build-up of strength and mass is noticed. That's why it's often used at the beginning of cycle consisting of mostly injectables like long-acting testosterone esters and nandrolone. Since the effects of such drugs don't fully come out for the first 10-15 days, Dianabol is dosed in to provide immediate and visible results.
It has a rather weak androgenic component and an obviously quite strong and visible anabolic component. Its effects are largely non-AR mediated, which is documented by its rather low influence on the natural endocrine system2 and the fact that it decreases rather than increases red blood cell content in the blood. Which means that one worry users of Dianabol, especially short term, needn't fear is the dramatic shutdown of natural testosterone production as is often the case with very androgenic compounds. Of course this effect is dose-dependent.
It still has a mild androgenic component, meaning in high doses (30+ mg daily) androgen-mediated side-effects can be noted (acne, male pattern hair loss).
Because of its fast effects, immense popularity and the increasing 'more-is-better' sentiment among bodybuilders, increasingly high doses are indeed being used and recommended. One has to wonder about the logic of such recommendations however, since high dose urine-analysis showed portions of unmetabolized compounds were being excreted3.
In simpler terms that means that with higher doses, higher amounts of unchanged Dianabol were being excreted in the urine. This would indicate that the current stance needs to be reviewed and that smaller doses, taken multiple times per day would deliver better results and maximal use of the steroid. Dianabol simply is highly effective in low doses (25-40 mg ed).
Some say Anadrol, a comparable steroid to Dianabol, is better, but its taken in doses of 50-150 mg. If one was to take Dianabol in those doses better gains could be expected. Dianabol is also a lot safer in as opposed to the highly toxic and progestagenic anadrol.
If one takes into account that the half-life of Dianabol in the body is only 3-6 hours, this theory makes even more sense. So taking your daily dose spread over 3 or 4 doses may elicit a better effect than only 1 or 2 doses.
Dianabol is quite effective in these lower doses by the way. Milligram for Milligram its more powerful than a testosterone ester, generally considered the best mass-builder.
A few notes there need to be made however. Not everyone should try and spread their doses out over multiple servings. First of all there is a slightly lower efficacy to take into account here as well due to two characteristics. The first being that you feed the total amount to the liver in smaller portions, yet the liver still manages to metabolise the same amount.
Percentage wise that means less methandienone would make it through totally. The second would be that the peak levels aren't quite as high since no large doses are taken all at once. These two facts make it hard to recommend that just anyone take multiple doses. People who take moderate to low doses of ONLY Dianabol should probably opt for a single morning dose.
This delivers a higher peak level and more survival of your only steroid. It also, due to the short half-life, makes the drug clear the body before the body produces its largest dose of natural testosterone, the early hours of sleep. Combined with the already mild effect at the AR, you could keep a good amount of your gains when using clomid or Nolvadex post-cycle. For those using it in conjunction with other, mostly injectable steroids, two doses seems to be the better choice, if you are taking in excess of 40 mg a day perhaps even three doses.
This is usually the case for fast-acting substances, they have short half-lives. Which brings us to the point of prolonged use. The general consensus is that Dianabol should never be used more than 6 weeks on end due its strong hepatoxic effects. Being largely an oral compound, it's also 17-alpha-alkylated to help it survive the liver upon first pass.
Liver values are elevated over a short period of time4, making long-term use a very dangerous affair. Liver values should return to normal quite fast after discontinuation however since the effects are so short-lived. Other risks associated with the use of Dianabol include the apparition of estrogenic side-effects because it interacts rather well with the aromatase enzyme on account of its methylated properties. It is therefore best used in conjunction with an anti-estrogen.
Gynocomastia, high blood pressure, salt and water retention and mild cases of acne are therefore not uncommon.
Its methylated properties (17-methyl group) does have several positive characteristics of course. Why else would they add this group? The main purpose of course it to make sure less of the Dianabol is affected by hepatic breakdown when taken orally. But apparently it also decreases the affinity of the drug to SHBG (sex-hormone binding globulin), a sex steroid binding protein that takes up as much as 98% of testosterone.